PEPCK-M recoups tumor cell anabolic potential in a PKC-ζ-dependent manner

Abstract Background Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M; PCK2) is expressed in all cancer types examined and in neuroprogenitor cells. The gene is upregulated by amino acid limitation and ER-stress in an ATF4-dependent manner, and its activity modulates the PEP/Ca2+ signaling ax...

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Bibliografiske detaljer

Principais autores:	Petra Hyroššová, Marc Aragó, Juan Moreno-Felici, Xiarong Fu, Andrés Mendez-Lucas, Pablo M. García-Rovés, Shawn Burgess, Agnès Figueras, Francesc Viñals, Jose C. Perales
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMC 2021-01-01
Serier:	Cancer & Metabolism
Fag:	PEPCK PEPCK-M PCK2 Phosphoenolpyruvate carboxykinase Cancer metabolism PEP
Online adgang:	https://doi.org/10.1186/s40170-020-00236-3
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