A simple, sensitive method for the simultaneous determination of cotinine and trans-3´-hydroxycotinine in human serum by LC-MS/MS
Abstract A simple and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous determination of cotinine and its metabolite, trans-3´-hydroxycotinine, in human serum. Liquid–liquid extraction (LLE) using dichloromethane (DCM) and eth...
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| Principais autores: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
SpringerOpen
2025-05-01
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| Serier: | Journal of Analytical Science and Technology |
| Fag: | |
| Online adgang: | https://doi.org/10.1186/s40543-025-00488-y |
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