Routine Cerebrospinal Fluid (CSF) Parameters in Patients With Spinal Muscular Atrophy (SMA) Treated With Nusinersen

Background: Nusinersen is an antisense-oligonucleotide (ASO) approved for treatment of 5q-spinal muscular atrophy (SMA). Since the drug cannot cross the blood-brain barrier (BBB), it must be administered into the cerebrospinal fluid (CSF) space repeatedly by lumbar puncture. However, little is known...

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Detalles Bibliográficos

Principais autores:	Claudia D. Wurster, Jan C. Koch, Isabell Cordts, Jens Dreyhaupt, Markus Otto, Zeljko Uzelac, Simon Witzel, Benedikt Winter, Tugrul Kocak, Michael Schocke, Patrick Weydt, Kurt Wollinsky, Albert C. Ludolph, Marcus Deschauer, Paul Lingor, Hayrettin Tumani, Andreas Hermann, René Günther
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2019-11-01
Series:	Frontiers in Neurology
Assuntos:	spinal muscular atrophy motor neuron disease antisense-oligonucleotide routine CSF parameters lumbar puncture
Acceso en liña:	https://www.frontiersin.org/article/10.3389/fneur.2019.01179/full
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