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Angiopoietin-like protein 8 orchestrates macrophage glycogen metabolism and polarization via the JNK signaling pathway in cytokine storm syndrome

Abstract Cytokine storm syndrome (CSS) is associated with severe damage and high mortality in acute diseases. Over-activation of M1 macrophages, accompanied with excessive pro-inflammatory cytokine secretion, drives cytokine storms, while promoting M2 macrophage polarization is a potential CSS treat...

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Furkejuvvon:
Váldodahkkit: Yang Su, Rongtian Zhang, Kongdong Li, Hong Shen, Mengjiao Nan, Chang Liu, Wenxiang Zhang, Siyu Chen
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: BMC 2025-10-01
Ráidu:Cell & Bioscience
Fáttát:
Cytokine storm syndrome
Angptl8
Macrophage polarization
Glycogen metabolism
Liver
Liŋkkat:https://doi.org/10.1186/s13578-025-01487-7
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