ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy

HIV infection leads to a phenomenon of inflammaging, in which chronic inflammation induces an immune aged phenotype, even in individuals on combined antiretroviral therapy (cART) with undetectable viremia. In this study, we investigated T cell homeostasis and telomeric DNA damage and repair machiner...

Descripció completa

Dades bibliogràfiques

Autors principals:	Juan Zhao, Lam Ngoc Thao Nguyen, Lam Nhat Nguyen, Xindi Dang, Dechao Cao, Sushant Khanal, Madison Schank, Bal Krishna Chand Thakuri, Stella C. Ogbu, Zheng D. Morrison, Xiao Y. Wu, Zhengke Li, Yue Zou, Mohamed El Gazzar, Shunbin Ning, Ling Wang, Jonathan P. Moorman, Zhi Q. Yao
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2019-11-01
Col·lecció:	Frontiers in Immunology
Matèries:	ATM apoptosis DNA damage repair immune aging HIV T cell homeostasis
Accés en línia:	https://www.frontiersin.org/article/10.3389/fimmu.2019.02531/full
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!