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Apigenin and Luteolin Regulate Autophagy by Targeting NRH-Quinone Oxidoreductase 2 in Liver Cells

Dietary flavonoids stimulate autophagy and prevent liver dysfunction, but the upstream signaling pathways triggered by these compounds are not well understood. Certain polyphenols bind directly to NRH-quinone oxidoreductase 2 (NQO2) and inhibit its activity. NQO2 is highly expressed in the liver, wh...

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Principais autores: Elzbieta Janda, Concetta Martino, Concetta Riillo, Maddalena Parafati, Antonella Lascala, Vincenzo Mollace, Jean A. Boutin
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-05-01
Serier:Antioxidants
Fag:
polyphenol
quinone reductase
menadione
autophagy
flavoenzyme
IC50
Online adgang:https://www.mdpi.com/2076-3921/10/5/776
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