Therapeutic cancer vaccination against mutant calreticulin in myeloproliferative neoplasms induces expansion of specific T cells in the periphery but specific T cells fail to enrich in the bone marrow

BackgroundTherapeutic cancer vaccination against mutant calreticulin (CALR) in patients with CALR-mutant (CALRmut) myeloproliferative neoplasms (MPN) induces strong T-cell responses against mutant CALR yet fails to demonstrate clinical activity. Infiltration of tumor specific T cells into the tumor...

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Автори:	Morten Orebo Holmström, Morten Andersen, Sofie Traynor, Shamaila Munir Ahmad, Thomas Landkildehus Lisle, Jacob Handlos Grauslund, Vibe Skov, Lasse Kjær, Johnny T. Ottesen, Morten Frier Gjerstorff, Hans Carl Hasselbalch, Mads Hald Andersen
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Frontiers Media S.A. 2023-08-01
Серія:	Frontiers in Immunology
Предмети:	myeloproliferative neoplasms calreticulin cancer vaccines immune escape adaptive immunity
Онлайн доступ:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1240678/full
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