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Targeted lipid nanoparticles containing IL-10 mRNA improve outcomes in experimental intracerebral hemorrhage

Abstract Intracerebral hemorrhage (ICH) is a lethal and highly morbid form of stroke for which there is no disease-specific therapy. Inflammation after ICH is an important mechanism of secondary damage, and the inflamed endothelium in ICH is a promising therapeutic target as it is the gateway for re...

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Principais autores: Sahily Reyes-Esteves, Aparajeeta Majumder, Nicolas Marzolini, Marco E. Zamora, Soomin Jeong, Yufei Wang, Manthan N. Patel, Carolann Espy, Tyler Ellis Papp, Awurama Akyianu, Jia Nong, Lawson Messe, Serena Omo-Lamai, Hamideh Parhiz, Jacob W. Myerson, Oscar A. Marcos-Contreras, Jacob S. Brenner
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-10-01
coleção:Journal of Neuroinflammation
Assuntos:
Intracerebral hemorrhage
Endothelial inflammation
Targeted nanoparticles
Brain drug delivery
Hemorrhagic stroke
Acesso em linha:https://doi.org/10.1186/s12974-025-03541-0
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