Implications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function
Integrins are transmembrane receptors composed of α and β subunits. Although most integrins contain β1, canonical activation mechanisms are based on studies of the platelet integrin, αIIbβ3. Its inactive conformation is characterized by the association of the αIIb transmembrane and cytosolic domain...
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| Huvudupphov: | , , , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
eLife Sciences Publications Ltd
2016-12-01
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| Serie: | eLife |
| Ämnen: | |
| Länkar: | https://elifesciences.org/articles/18633 |
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