α-GalCer-LNP ehanced mRNA delivery and activates natural killer T cells for superior tumor immunotherapy

Lipid nanoparticles (LNPs) have emerged as a clinically validated platform for cancer immunotherapy; however, challenges remain in optimizing RNA delivery and promoting synergistic immune activation. To address these issues, we developed a modified LNP system that incorporates α-galactosylceramide (...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Kexin Zhang, Zhen Xu, Zexiu Xiao, Fei Cao, Jing Wang, Yuandong Xu, Winson M.J. Ma, Sihui Long, Gao-Feng Zha
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Elsevier 2025-06-01
Σειρά:	Materials Today Bio
Θέματα:	Lipid nanoparticles α-GalCer Natural killer T mRNA vaccine Cancer immunotherapy
Διαθέσιμο Online:	http://www.sciencedirect.com/science/article/pii/S2590006425004533
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