Divergent Pseudomonas aeruginosa LpxO enzymes perform site-specific lipid A 2-hydroxylation

ABSTRACT Pseudomonas aeruginosa can survive in a myriad of environments, partially due to modifications of its lipid A, the membrane anchor of lipopolysaccharide. We previously demonstrated that divergent late acyltransferase paralogs, HtrB1 and HtrB2, add acyloxyacyl laurate to lipid A 2- and 2′-ac...

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Detalhes bibliográficos

Principais autores:	Casey E. Hofstaedter, Courtney E. Chandler, Charles M. Met, Joseph J. Gillespie, Janette M. Harro, David R. Goodlett, David A. Rasko, Robert K. Ernst
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2024-02-01
coleção:	mBio
Assuntos:	lipid A Pseudomonas cystic fibrosis dioxygenases LPS evolution
Acesso em linha:	https://journals.asm.org/doi/10.1128/mbio.02823-23
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