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Low and differential polygenic score generalizability among African populations due largely to genetic diversity

Summary: African populations are vastly underrepresented in genetic studies but have the most genetic variation and face wide-ranging environmental exposures globally. Because systematic evaluations of genetic prediction had not yet been conducted in ancestries that span African diversity, we calcul...

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Asıl Yazarlar: Lerato Majara, Allan Kalungi, Nastassja Koen, Kristin Tsuo, Ying Wang, Rahul Gupta, Lethukuthula L. Nkambule, Heather Zar, Dan J. Stein, Eugene Kinyanda, Elizabeth G. Atkinson, Alicia R. Martin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2023-04-01
Seri Bilgileri:HGG Advances
Konular:
polygenic scores
Africa
GWAS
health disparities
global health
population genetics
Online Erişim:http://www.sciencedirect.com/science/article/pii/S2666247723000167
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