FBXL6 governs c-MYC to promote hepatocellular carcinoma through ubiquitination and stabilization of HSP90AA1

Abstract Background Heat shot protein 90 (HSP90) AA1 functions as an onco-protein to regulate the assembly, manipulation, folding and degradation of its client proteins, including c-MYC. However, little is known about the mechanism of HSP90AA1 regulation. Methods Transcriptome RNA-sequencing data of...

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Autori principali:	Weidong Shi, Lanyun Feng, Shu Dong, Zhouyu Ning, Yongqiang Hua, Luming Liu, Zhen Chen, Zhiqiang Meng
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2020-06-01
Serie:	Cell Communication and Signaling
Soggetti:	Hepatocellular carcinoma Heat shock proteins HSP90AA1 SCF complex C-MYC FBXL6
Accesso online:	http://link.springer.com/article/10.1186/s12964-020-00604-y
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