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Fokker-Planck diffusion maps of microglial transcriptomes reveal radial differentiation into substates associated with Alzheimer’s pathology

Abstract The identification of microglia subtypes is important for understanding the role of innate immunity in neurodegenerative diseases. Current methods of unsupervised cell type identification assume a small noise-to-signal ratio of transcriptome measurements to produce well-separated cell clust...

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-д хадгалсан:
Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Andrew Baumgartner, Max Robinson, Nilufer Ertekin-Taner, Todd E. Golde, Suman Jaydev, Sui Huang, Jennifer Hadlock, Cory Funk
Формат: Artigo
Хэл сонгох:Inglês
Хэвлэсэн: Nature Portfolio 2025-02-01
Цуврал:Communications Biology
Онлайн хандалт:https://doi.org/10.1038/s42003-025-07594-y
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