Perampanel reduces seizure frequency in patients with developmental and epileptic encephalopathy for a long term

Abstract Seizures in patients with developmental and epileptic encephalopathies (DEEs) are often highly resistant to various antiseizure medications. Perampanel (PER) is a novel antiseizure medication that non-competitively inhibits the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor a...

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Autori principali:	Hirokazu Yamagishi, Hitoshi Osaka, Kazuhiro Muramatsu, Karin Kojima, Yukifumi Monden, Tadahiro Mitani, Yuta Asakura, Keizo Wakae, Kohei Nagai, Toshihiro Tajima
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2024-12-01
Serie:	Scientific Reports
Soggetti:	Perampanel Lennox-Gastaut syndrome Epilepsy with myoclonic atonic seizures Long-term Efficacy & safety
Accesso online:	https://doi.org/10.1038/s41598-024-82014-5
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