Single-cell and spatial-resolved profiling reveals cancer-associated fibroblast heterogeneity in colorectal cancer metabolic subtypes

Abstract Background Colorectal cancer (CRC) presents significant treatment challenges due to its high heterogeneity and complex intercellular interactions. Further exploration of CRC subtypes and interactions among tumor-specific clusters will facilitate the development of personalized treatment str...

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Detalhes bibliográficos

Principais autores:	Youpeng Wang, Xingfeng Qiu, Qinghai Li, Jiale Qin, Lvlan Ye, Xiang Zhang, Xingxiang Huang, Xiangqiong Wen, Ziyang Wang, Weiling He, Yuqin Di, Qi Zhou
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-02-01
coleção:	Journal of Translational Medicine
Assuntos:	Colorectal cancer Single-cell RNA sequencing Cancer-associated fibroblast (CAF) Chemoresistance
Acesso em linha:	https://doi.org/10.1186/s12967-025-06103-3
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