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Blockade of the PD-1/PD-L1 Immune Checkpoint Pathway Improves Infection Outcomes and Enhances Fungicidal Host Defense in a Murine Model of Invasive Pulmonary Mucormycosis

Anecdotal clinical reports suggested a benefit of adjunct immune checkpoint inhibitors (ICIs) to treat invasive mucormycosis. However, proof-of-concept data in animal models and mechanistic insights into the effects of ICIs on host defense against Mucorales are lacking. Therefore, we studied the eff...

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Autori principali: Sebastian Wurster, Nathaniel D. Albert, Uddalak Bharadwaj, Moses M. Kasembeli, Jeffrey J. Tarrand, Naval Daver, Dimitrios P. Kontoyiannis
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2022-02-01
Serie:Frontiers in Immunology
Soggetti:
mucormycosis
animal model
checkpoint inhibitors
immunotherapy
T cells
cytokines
Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2022.838344/full
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