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Neurosteroid Modulation of Synaptic and Extrasynaptic GABA<sub>A</sub> Receptors of the Mouse Nucleus Accumbens

The recent approval of formulations of the endogenous neurosteroid allopregnanolone (brexanolone) and the synthetic neuroactive steroid SAGE-217 (zuranolone) to treat postpartum depression (PPD) has encouraged further research to elucidate why these potent enhancers of GABA<sub>A</sub>R function are...

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Sparad:
Huvudupphov: Scott J. Mitchell, Grant D. Phillips, Becks Tench, Yunkai Li, Delia Belelli, Stephen J. Martin, Jerome D. Swinny, Louise Kelly, John R. Atack, Michael Paradowski, Jeremy J. Lambert
Materialtyp: Artigo
Språk:Inglês
Utgiven: MDPI AG 2024-04-01
Serie:Biomolecules
Ämnen:
allopregnanolone
brexanolone
zuranolone GABAA receptor
tonic inhibition
phasic inhibition
nucleus accumbens
Länkar:https://www.mdpi.com/2218-273X/14/4/460
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