Generation and preclinical characterization of a novel bispecific CD19-TCRgammadelta antibody for the treatment of B cell acute lymphoblastic leukemia

IntroductionB-cell acute lymphoblastic leukemia (B-ALL) is characterized by the clonal expansion of immature lymphoblastic cells. Treating patients with disease relapse is challenging, especially after allogeneic stem cell transplantation (aSCT). Although the CD19xCD3 bispecific antibody (bsAb) blin...

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Principais autores:	Joseph Kauer, Fabian Vogt, Sebastian Hörner, Valentin Schmidt, Carsten Müller-Tidow, Simon Raffel, Helmut R. Salih, Gundram Jung, Martin Pflügler
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2026-02-01
Series:	Frontiers in Immunology
Assuntos:	acute lymphoblastic leukemia bispecific antibodies CD19 gammadelta T cells immunotherapy
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1728424/full
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