Daughterless, the Drosophila orthologue of TCF4, is required for associative learning and maintenance of the synaptic proteome

Mammalian transcription factor 4 (TCF4) has been linked to schizophrenia and intellectual disabilities, such as Pitt–Hopkins syndrome (PTHS). Here, we show that similarly to mammalian TCF4, fruit fly orthologue Daughterless (Da) is expressed widely in the Drosophila brain. Furthermore, silencing of...

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Detalhes bibliográficos

Principais autores:	Laura Tamberg, Mariliis Jaago, Kristi Säälik, Alex Sirp, Jürgen Tuvikene, Anastassia Shubina, Carl Sander Kiir, Kaja Nurm, Mari Sepp, Tõnis Timmusk, Mari Palgi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	The Company of Biologists 2020-07-01
Colecção:	Disease Models & Mechanisms
Assuntos:	tcf4 daughterless pitt–hopkins syndrome intellectual disability drosophila melanogaster appetitive associative learning negative geotaxis
Acesso em linha:	http://dmm.biologists.org/content/13/7/dmm042747
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