HIV-1 structural proteins serve as PAMPs for TLR2 heterodimers significantly increasing infection and innate immune activation

Immune activation is critical to HIV infection and pathogenesis; however, our understanding of HIV innate immune activation remains incomplete. Recently we demonstrated that soluble TLR2 (sTLR2) physically inhibited HIV-induced, NFκB activation and inflammation, as well as HIV-1 infection. In light...

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Principais autores:	Kenneth Lee Rosenthal, Bethany M Henrick, Xiao-Dan eYao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2015-08-01
coleção:	Frontiers in Immunology
Assuntos:	Inflammation innate immunity immune activation Toll-like receptors (TLRs) Pattern recognition receptors (PRRs) Human immunodeficiency virus type 1 (HIV-1)
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00426/full
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