CU Cilia – an application for image analysis by machine learning – reveals significance of cysteine cathepsin K activity for primary cilia of human thyroid epithelial cells

IntroductionCysteine cathepsins K and L are crucial for proper thyroid function in mice. Inhibition of cysteine peptidases in rodent thyroid epithelial cells in vitro results in loss of primary cilia, highlighting the significance of proteolysis for cilia maintenance.MethodsIn this study, we used an...

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Hlavní autoři:	Maren Rehders, Kseniia Alekseitseva, João Gissoni, Alara G. Doğru, Petr Popov, Andrei Boiarov, Klaudia Brix
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-11-01
Edice:	Frontiers in Endocrinology
Témata:	cysteine cathepsins image analysis machine learning neural network pre-training odanacatib primary cilia
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fendo.2025.1588394/full
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