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Impairment of novelty-dependent hippocampal behavioural tagging in Septin5-deficient mice

Abstract Septin-5 is a GTP-binding protein implicated in synaptic vesicle exocytosis and 22q11.2 deletion–related neuropsychiatric disorders. We recently showed that Septin5-deficient (Septin5 −/−) mice display intact hippocampal spine ultrastructure, but marked deficits in both recent and remote co...

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Principais autores: Natsumi Ageta-Ishihara, Naoto Fukumasu, Kazuki Fujii, Yumie Koshidaka, Kenji Tanigaki, Takeshi Hiramoto, Gina Kang, Noboru Hiroi, Tsuyoshi Miyakawa, Keizo Takao, Makoto Kinoshita
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-02-01
Serier:Molecular Brain
Fag:
Septins
Septin-5
Hippocampus
Behavioural tagging
Online adgang:https://doi.org/10.1186/s13041-026-01276-4
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