Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases

Abstract Background Autosomal dominant mutations in α-synuclein, TDP-43 and tau are thought to predispose to neurodegeneration by enhancing protein aggregation. While a subset of α-synuclein, TDP-43 and tau mutations has been shown to increase the structural propensity of these proteins toward self-...

Descripció completa

Dades bibliogràfiques

Autors principals:	Paul J. Sampognaro, Shruti Arya, Giselle M. Knudsen, Emma L. Gunderson, Angelica Sandoval-Perez, Molly Hodul, Kathryn Bowles, Charles S. Craik, Matthew P. Jacobson, Aimee W. Kao
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2023-05-01
Col·lecció:	Molecular Neurodegeneration
Matèries:	Cathepsin Protease α-synuclein TDP-43 Tau Lysosome
Accés en línia:	https://doi.org/10.1186/s13024-023-00621-8
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!