Identification of a new member of Mortaparib class of inhibitors that target mortalin and PARP1
Mortalin, a heat shock family protein enriched in cancer cells, is known to inactivate tumor suppressor protein p53. Abrogation of mortalin-p53 interaction and reactivation of p53 has been shown to trigger growth arrest/apoptosis in cancer cells and hence, suggested to be useful in cancer therapy. I...
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| Principais autores: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Frontiers Media S.A.
2022-09-01
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| Serier: | Frontiers in Cell and Developmental Biology |
| Fag: | |
| Online adgang: | https://www.frontiersin.org/articles/10.3389/fcell.2022.918970/full |
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