Caveolin-1 drives immunosuppression in esophageal squamous cell carcinoma by enhancing exosome secretion and macrophage M2 polarization via inhibition of MVB autophagic degradation

Abstract Background Exosomes are pivotal mediators of molecular transfer and intercellular communication, orchestrating interactions between tumor cells and the tumor microenvironment (TME). However, the impact of exosomes derived from esophageal squamous cell carcinoma (ESCC) on macrophages and the...

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Egile Nagusiak:	Ke-Rong Zhai, Pei-Lin Zhao, Zi-Han Wang, Hai-Ming Feng, Zhen-Qing Li, Hui-Rong Huang, Ning Yang, Zhi-Peng Su, Bai-Qiang Cui, Tie-Niu Song, Bin Li
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	BMC 2026-02-01
Saila:	Journal of Translational Medicine
Gaiak:	Esophageal squamous cell carcinoma Caveolin-1 Exosomes M2 macrophage polarization Tumor microenvironment
Sarrera elektronikoa:	https://doi.org/10.1186/s12967-026-07800-3
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