A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma

Temozolomide (TMZ) resistance in glioblastomas (GBM) is associated with increased MGMT expression. Here, the authors identify an enhancer between the promoters of MKI67 and MGMT, that when activated drives MGMT expression despite MGMT promoter methylation to confer TMZ resistance in GBM.

Dades bibliogràfiques

Autors principals:	Xiaoyue Chen, Minjie Zhang, Haiyun Gan, Heping Wang, Jeong-Heon Lee, Dong Fang, Gaspar J. Kitange, Lihong He, Zeng Hu, Ian F. Parney, Fredric B. Meyer, Caterina Giannini, Jann N. Sarkaria, Zhiguo Zhang
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2018-07-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-018-05373-4
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