Inhibition of endocannabinoid degradation in astrocytes reprograms glial reactivity and prevents seizure sequelae

Abstract Background Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy and is characterized by a pathological cascade of excitotoxicity that leads to neuroinflammation, progressive neuronal loss, and subsequent cognitive decline. Despite its prevalence, effective therapies remain...

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Hlavní autoři:	Chudai Zeng, Fei Gao, Mei Hu, Jian Zhang, Dexiao Zhu, Li Sun, Jianlu Lyu, Mingzhe Pan, Chu Chen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-05-01
Edice:	Journal of Neuroinflammation
Témata:	Epilepsy 2-arachidonylglycerol Monoacylglycerol lipase Cannabinoid receptor Astrocyte Neuroinflammation
On-line přístup:	https://doi.org/10.1186/s12974-026-03883-3
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