Pre-clinical drug-drug interaction (DDI) of gefitinib or erlotinib with Cytochrome P450 (CYP) inhibiting drugs, fluoxetine and/or losartan

Objective: To evaluate drug-drug interactions (DDIs) between gefitinib or erlotinib with fluoxetine, and/or losartan. Methods: Human pooled microsomes, supersomes, and cryopreserved human hepatocytes were used to monitor DDIs in vitro. RED (Rapid Equilibrium Dialysis) protein binding was employed to...

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Egile Nagusiak:	Thu-Lan T. Luong, Michael J. McAnulty, David L. Evers, Brian J. Reinhardt, Peter J. Weina
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Elsevier 2021-01-01
Saila:	Current Research in Toxicology
Gaiak:	Drug-Drug Interaction Erlotinib Gefitinib Fluoxetine Losartan Cytochrome P450
Sarrera elektronikoa:	http://www.sciencedirect.com/science/article/pii/S2666027X21000232
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