Lysophosphatidic acid suppresses apoptosis of high-grade serous ovarian cancer cells by inducing autophagy activity and promotes cell-cycle progression via EGFR-PI3K/Aurora-AThr288-geminin dual signaling pathways

Lysophosphatidic acid (LPA) and geminin are overexpressed in ovarian cancer, and increasing evidence supports their contribution to ovarian tumor development. Here, we reveal that geminin depletion induces autophagy suppression and enhances reactive oxygen species (ROS) production and apoptosis of h...

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Bibliografische Detailangaben

Hauptverfasser:	Haile Zhao, Peijun Jia, Kathleen Nanding, Man Wu, Xiaozhou Bai, Morigen Morigen, Lifei Fan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2022-12-01
Schriftenreihe:	Frontiers in Pharmacology
Schlagworte:	LPA geminin EGFR transactivation autophagy apoptosis Aurora-AThr288
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fphar.2022.1046269/full
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