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Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders

Many postnatal onset neurological disorders such as autism spectrum disorders (ASDs) and intellectual disability are thought to arise largely from disruption of excitatory/inhibitory homeostasis. Although mouse models of Rett syndrome (RTT), a postnatal neurological disorder caused by loss-of-functi...

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Main Authors: Xiangling Meng, Wei Wang, Hui Lu, Ling-jie He, Wu Chen, Eugene S Chao, Marta L Fiorotto, Bin Tang, Jose A Herrera, Michelle L Seymour, Jeffrey L Neul, Fred A Pereira, Jianrong Tang, Mingshan Xue, Huda Y Zoghbi
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications Ltd 2016-06-01
Series:eLife
Subjects:
glutamatergic neurons
neurological disorders
MeCP2
Rett syndrome
Online Access:https://elifesciences.org/articles/14199
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