New insights into the responder/nonresponder divide in rectal cancer: Damage-induced Type I IFNs dictate treatment efficacy and can be targeted to enhance radiotherapy

Abstract Rectal cancer ranks as the second leading cause of cancer-related deaths. Neoadjuvant therapy for rectal cancer patients often results in individuals that respond well to therapy and those that respond poorly, requiring life-altering excision surgery. It is inadequately understood what dict...

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Hauptverfasser:	Taylor P. Uccello, Maggie L. Lesch, Sarah A. Kintzel, Lauren B. Gradzewicz, Lillia Lamrous, Shawn P. Murphy, Fergal J. Fleming, Bradley N. Mills, Joseph D. Murphy, Angela Hughson, Gary Hannon, Jesse Garrett-Larsen, Haoming Qiu, Michael G. Drage, Jian Ye, Nicholas W. Gavras, David C. Keeley, Tanzy M. T. Love, Elizabeth A. Repasky, Edith M. Lord, David C. Linehan, Scott A. Gerber
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2023-07-01
Schriftenreihe:	Cell Death and Disease
Online-Zugang:	https://doi.org/10.1038/s41419-023-05999-3
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