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The impact of interferon-γ pathway on trained immunity induction by vaccination with Bacille Calmette-Guérin

Abstract Bacillus Calmette-Guérin (BCG) has multiple heterologous off-target effects which extend beyond tuberculosis (TB) prophylaxis, which include protection against other non-tuberculous infections, autoimmune diseases, and tumor development. These heterologous effects are at least partially med...

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Tallennettuna:
Päätekijät: Ekaterina Isachesku, Andrei Cismaru, Vasiliki Matzaraki, Simone J. C. F. M. Moorlag, Vera P. Mourits, Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Leo A. B. Joosten, Ioana Berindan-Neagoe, Mihai G. Netea
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Portfolio 2025-10-01
Sarja:Scientific Reports
Aiheet:
BCG
Trained immunity
Interferon-γ
Cytokine response
Genetic variation
Linkit:https://doi.org/10.1038/s41598-025-16350-5
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