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A self-assembled nanoparticle vaccine displaying chimeric and trimeric RBD-HRC elicits broad-spectrum neutralizing antibodies against multiple coronaviruses

ABSTRACT Coronaviruses, known for their high mutation rates and character of cross-species transmission, continue to pose significant threats to global health, as demonstrated by outbreaks of SARS, MERS, and SARS-CoV-2. Vaccines remain the most effective means of preventing viral infection, transmis...

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Principais autores: Didi Wan, Lili Li, He Feng, Mengyu Wang, Shuo Jia, Pengyu Zhang, Jiaxu Wang, Junxia Yang, Yijie Zhang, Boya Ji, Yushun Wan, Zhengkun Xie, Jian Shang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2026-05-01
coleção:Microbiology Spectrum
Assuntos:
nanoparticle
broad-spectrum
vaccine design
coronaviruses
Acesso em linha:https://journals.asm.org/doi/10.1128/spectrum.03797-25
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