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Identification and Validation of Afatinib Potential Drug Resistance Gene BIRC5 in Non-Small Cell Lung Cancer

IntroductionResistance to second-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), afatinib, is the most significant challenge in the clinical management of non-small cell lung cancer (NSCLC), and the underlying mechanisms remain unclear.MethodsGenomic signatures that...

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Principais autores: Xiaoxi Zhu, Renyu Zhou, Yuanzhi Lu, Ying Zhang, Qiang Chen, Yin Li
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-11-01
Serier:Frontiers in Oncology
Fag:
bioinformatic analysis
NSCLC
afatinib resistance
BIRC5
TKI
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2021.763035/full
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