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Piperlongumine conquers temozolomide chemoradiotherapy resistance to achieve immune cure in refractory glioblastoma via boosting oxidative stress-inflamation-CD8+-T cell immunity

Abstract Background The failure of novel therapies effective in preclinical animal models largely reflects the fact that current models do not really mimic the pathological/therapeutic features of glioblastoma (GBM), in which the most effective temozolomide chemoradiotherapy (RT/TMZ) regimen can onl...

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Principais autores: Feng Liu, Qian Zhou, Hai-feng Jiang, Ting-ting Zhang, Cheng Miao, Xiao-hong Xu, Jia-xing Wu, Song-lin Yin, Shi-jie Xu, Jing-yi Peng, Pan-pan Gao, Xuan Cao, Feng Pan, Ximiao He, Xiao Qian Chen
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-05-01
Serier:Journal of Experimental & Clinical Cancer Research
Fag:
Piperlongumine
Glioma
Tumor microenvironment
ROS generation/elimination
Immunotherapy
PD-1
Online adgang:https://doi.org/10.1186/s13046-023-02686-1
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