IFNL4 genotype is associated with hepatitis A virus infection findings from a focused phenotype study in the UK Biobank Cohort

Background: The IFNL4-ΔG/TT (rs368234815) polymorphism controls production of the IFN-λ4 protein; the IFNL4-ΔG allele generates IFN-λ4, IFNL4-TT disrupts IFN-λ4 production. Individuals who carry IFNL4-ΔG have impaired clearance of hepatitis C virus (HCV), but less hepatic inflammation in the face of...

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Auteurs principaux:	Neha Agarwala, Minkyo Song, Marc G. Ghany, Aubrey K. Hubbard, William Wheeler, Eric Engels, Ludmila Prokunina-Olsson, Mitchell J. Machiela, Ruth M. Pfeiffer, Thomas R. O’Brien
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2026-04-01
Collection:	International Journal of Infectious Diseases
Sujets:	Epidemiology Human genetics Immunology Liver
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S1201971226001189
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