Advancing artemisinin resistance monitoring using a high sensitivity ddPCR assay for Pfkelch13 mutation detection in Asia

Abstract The spread of Pfkelch13 mutations in Southeast Asia threatens the effectiveness of artemisinin-based combination therapies (ACTs) for malaria. Previous studies revealed a high prevalence of key mutations, including C580Y, P574L, and R561H, emphasizing the need for the surveillance to combat...

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Bibliografische Detailangaben

Hauptverfasser:	Suttipat Srisutham, Aungkana Saejeng, Nardlada Khantikul, Rungniran Sugaram, Raweewan Sangsri, Arjen M. Dondorp, Nicholas P. J. Day, Mallika Imwong
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-02-01
Schriftenreihe:	Scientific Reports
Schlagworte:	Plasmodium falciparum ddPCR Pfkelch13 Artemisinin resistance
Online-Zugang:	https://doi.org/10.1038/s41598-025-86630-7
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