Reshaping the tumor microenvironment of cold soft-tissue sarcomas with oncolytic viral therapy: a phase 2 trial of intratumoral JX-594 combined with avelumab and low-dose cyclophosphamide

Abstract Most soft-tissue sarcomas (STS) exhibit an immunosuppressive tumor microenvironment (TME), leading to resistance against immune checkpoint inhibitors (ICIs) and limited therapeutic response. Preclinical data suggest that oncolytic viral therapy can remodel the TME, facilitating T cell accum...

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Главные авторы:	Maud Toulmonde, Jean-Philippe Guegan, Mariella Spalato-Ceruso, Florent Peyraud, Michèle Kind, Lucile Vanhersecke, François Le Loarer, Raul Perret, Coralie Cantarel, Carine Bellera, Alban Bessede, Antoine Italiano
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2024-02-01
Серии:	Molecular Cancer
Предметы:	Soft-tissue sarcoma Oncolytic virus JX-594 Low-dose cyclophosphamide Avelumab
Online-ссылка:	https://doi.org/10.1186/s12943-024-01946-8
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