Effects of pentosan polysulfate sodium on synovial fluid biomarkers in moderate to severe knee osteoarthritis: an exploratory, phase 2, randomized, double-blind, placebo-controlled trial

Abstract Background To evaluate synovial fluid biomarkers of cartilage degradation, inflammation, and pain in participants with knee osteoarthritis pain treated with subcutaneous injectable pentosan polysulfate sodium (iPPS). Methods In an exploratory phase 2, double-blind trial, 61 participants wer...

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Autori principali:	Donna L. Skerrett, Catherine J. M. Stapledon, Mukesh Ahuja, Divya R. Navuru, Melanie J. Duiker, Ravi Krishnan, Thomas J. Schnitzer, Rachel A. Peat, Philip D. Bloom
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2026-01-01
Serie:	Arthritis Research & Therapy
Soggetti:	Osteoarthritis Randomized clinical trial Knee pain Synovial fluid Biomarkers PPS
Accesso online:	https://doi.org/10.1186/s13075-026-03740-x
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