In Silico and In Vitro Evaluation of the Mechanism of Action of Three VX809-Based Hybrid Derivatives as Correctors of the F508del CFTR Protein

Cystic fibrosis (CF), the most common autosomal recessive fatal genetic disease in the Caucasian population, is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), an anion channel that regulates salt and water transport across a variety of secret...

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Библиографические подробности

Главные авторы:	Debora Baroni, Naomi Scarano, Alessandra Ludovico, Chiara Brandas, Alice Parodi, Dario Lunaccio, Paola Fossa, Oscar Moran, Elena Cichero, Enrico Millo
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2023-12-01
Серии:	Pharmaceuticals
Предметы:	CFTR CFTR correctors <b>VX445</b> <b>VX661</b> molecular docking YFP functional assay
Online-ссылка:	https://www.mdpi.com/1424-8247/16/12/1702
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