STAT1 and m6A-mediated IL15RA upregulation promotes metastasis via ZEB1/NF-κΒ axis in ccRCC

Abstract Interleukin-15 receptor alpha (IL15RA) demonstrates critical regulatory function in oncogenesis and immunomodulation across various malignancies. However, the role of IL15RA in cancers, such as Clear Cell Renal Cell Carcinoma (ccRCC) remains unclear. Therefore, integrated pan-cancer analysi...

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Detalhes bibliográficos

Principais autores:	Jia Wei, Xuan’er Zhao, Huiping Wang, Cong Wang, Xinyi Liu, Zimeng Shan, Yican Guo, Xumeng Gu, Renren Li, Zhansheng Zhu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-10-01
coleção:	Scientific Reports
Assuntos:	IL15RA Clear cell renal cell carcinoma Metastasis m6A NF-κΒ ZEB1
Acesso em linha:	https://doi.org/10.1038/s41598-025-21947-x
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