Strategies to Circumvent the Side-Effects of Immunotherapy Using Allogeneic CAR-T Cells and Boost Its Efficacy: Results of Recent Clinical Trials

Despite the outstanding results of treatment using autologous chimeric antigen receptor T cells (CAR-T cells) in hematological malignancies, this approach is endowed with several constraints. In particular, profound lymphopenia in some patients and the inability to manufacture products with predefin...

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Principais autores:	Sergei Smirnov, Alexey Petukhov, Ksenia Levchuk, Sergey Kulemzin, Alena Staliarova, Kirill Lepik, Oleg Shuvalov, Andrey Zaritskey, Alexandra Daks, Olga Fedorova
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2021-12-01
Series:	Frontiers in Immunology
Assuntos:	chimeric allogeneic clinical trials GvHD receptor
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.780145/full
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