The nigrostriatal dopaminergic pathway mediates state-dependent emergence from propofol anesthesia in mice

The endogenous arousal pathway, centered around the midbrain dopaminergic (DA) system, plays a crucial role in regulating consciousness transitions. However, the role of substantia nigra pars compacta (SNc) DA neurons, particularly their projections to the dorsal striatum (DS), in propofol-induced u...

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Autores principales:	Yiqiu Chen, Shangqin Bai, Xiao Liu, Yu Li, Yanyan Ba, Yankai Wang, Peifu Zhang, Liliang Zhang, Lin Xue, Pei Sun, Wen Li, Xuejun Wang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2026-07-01
Colección:	Brain Research Bulletin
Materias:	General anesthesia Neural circuit Optogenetics Chemogenetics Substantia nigra pars compacta Nigrostriatal pathway
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S0361923026002121
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