Identification of epigenetic silencing of the SFRP2 gene in colorectal cancer as a clinical biomarker and molecular significance

Abstract Background Several studies have suggested secreted frizzled-related protein 2 (SFRP2) gene as a potential clinical biomarker in colorectal cancer (CRC). However, its diagnostic role remains unclear. In this study, we aimed to investigate the significance of SFRP2 methylation levels in a lar...

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Principais autores:	Hatim Boughanem, Jesús pilo, Libia Alejandra García-Flores, Isabel Arranz, María Ramos-Fernandez, María Ortega-Castan, Ana B. Crujeiras, Juan Sandoval, Manuel Macias-Gonzalez
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2024-05-01
Serija:	Journal of Translational Medicine
Teme:	SRFP2 DNA methylation Colorectal cancer biomarkers Promoter methylation Wnt signaling pathway
Online dostop:	https://doi.org/10.1186/s12967-024-05329-x
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