Effectiveness of TOcilizumab in comparison to Prednisone In Rheumatoid Arthritis patients with insufficient response to disease-modifying antirheumatic drugs (TOPIRA): study protocol for a pragmatic trial

Abstract Background Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, predominantly affecting joints, which is initially treated with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs). In RA patients with insufficient response to csDMARDs, the addition of...

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Hlavní autoři:	Matthijs S. van der Leeuw, Paco M. J. Welsing, Maria J. H. de Hair, Johannes W. G. Jacobs, Anne C. A. Marijnissen, Suzanne P. Linn-Rasker, Faouzia Fodili, Reinhard Bos, Janneke Tekstra, Jacob M. van Laar
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2020-04-01
Edice:	Trials
Témata:	Rheumatoid arthritis, Tocilizumab, Prednisone, Randomized controlled trial, Insufficient response to csDMARDs
On-line přístup:	http://link.springer.com/article/10.1186/s13063-020-04260-y
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