Targeting glycerophospholipid biosynthesis overcomes chemoresistance driven by SLFN11 loss in Ewing sarcoma

Abstract Ewing sarcoma (EWS) is a highly aggressive pediatric malignancy characterized by elevated expression of SLFN11, which impairs DNA repair by binding to and functionally inhibiting DNA repair complexes, thereby enhancing susceptibility to genotoxic therapies. However, relapse remains a major...

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Detalhes bibliográficos

Principais autores:	Kasturee Chakraborty, Ritambhar Burman, Saharsh Satheesh, Matthew Kieffer, Chandni Karuhatty, Zuo-Fei Yuan, Haiyan Tan, Ankhbayar Lkhagva, Anthony A. High, Xusheng Wang, Alaa Refaat, Nathaniel R. Twarog, Weixing Zhang, Yaxu Wang, Yiping Fan, Qian Li, M. Madan Babu, Anang A. Shelat, Elizabeth Stewart, Michael A. Dyer, Puneet Bagga
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2026-01-01
coleção:	Cell Death and Disease
Acesso em linha:	https://doi.org/10.1038/s41419-026-08432-7
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