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SECTM1 Regulates Monocyte Levels and Is Associated With Incident Coronary Heart Disease

Summary: Proteomic profiling may provide insights into new biomarkers and pathways in coronary heart disease (CHD). We profiled ∼1,300 proteins in 1,967 Black individuals in the Jackson Heart Study and found Secreted and Transmembrane Protein 1 (SECTM1), a monocyte chemoattractant, to be our top nov...

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Hoofdauteurs: Usman A. Tahir, MD, Daniel Cruz, MD, Dongxiao Shen, MS, Gaurav Tiwari, MS, Jing Liu, PhD, Matthew Huber, MD, Christopher Chan, MS, Shuliang Deng, MS, Mark D. Benson, MD, Jeremy Robbins, MD, Zsu Zsu Chen, MD, Laurie Farrell, BS, Lynette Ekunwe, MS, Michael Hall, MD, Bruce M. Psaty, MD, James S. Floyd, MD, Aarti Asnani, MD, Filip K. Swirski, PhD, James G. Wilson, MD, Robert E. Gerszten, MD
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2025-10-01
Reeks:JACC: Basic to Translational Science
Onderwerpen:
coronary heart disease
genomics
inflammation
monocytes
omics
proteomics
Online toegang:http://www.sciencedirect.com/science/article/pii/S2452302X25003316
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