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Combining mutation and recombination statistics to infer clonal families in antibody repertoires

B-cell repertoires are characterized by a diverse set of receptors of distinct specificities generated through two processes of somatic diversification: V(D)J recombination and somatic hypermutations. B-cell clonal families stem from the same V(D)J recombination event, but differ in their hypermutat...

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Principais autores: Natanael Spisak, Gabriel Athènes, Thomas Dupic, Thierry Mora, Aleksandra M Walczak
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications Ltd 2024-08-01
Series:eLife
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Acceso en liña:https://elifesciences.org/articles/86181
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