Edwardsiella ictaluri T3SS effector EseN is a phosphothreonine lyase that inactivates ERK1/2, p38, JNK, and PDK1 and modulates cell death in infected macrophages

ABSTRACT EseN is an Edwardsiella ictaluri type III secretion system effector with phosphothreonine lyase activity. In this work, we demonstrate that EseN inactivates p38 and c-Jun-N-terminal kinase (JNK) in infected head-kidney-derived macrophages (HKDMs). We have previously reported inactivation of...

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Autors principals:	Ranjan Koirala, Chanida Fongsaran, Tanisha Poston, Matthew Rogge, Bryan Rogers, Ronald Thune, Lidiya Dubytska
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology 2023-12-01
Col·lecció:	Microbiology Spectrum
Matèries:	Edwardsiella ictaluri type III secretion system T3SS effectors EseN apoptosis phosphothreonine lyase
Accés en línia:	https://journals.asm.org/doi/10.1128/spectrum.03003-23
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